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Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
Published on: November 1, 2019
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Acid-Triggered, Acid-Generating, and Self-Amplifying Degradable Polymers
Journal of the American Chemical Society
|January 31, 2019
Abstract:
We describe the 3-iodopropyl acetal moiety as a simple cleavable unit that undergoes acid catalyzed hydrolysis to liberate HI (p Ka ∼ -10) and acrolein stoichiometrically. Integrating this unit into linear and network polymers gives a class of macromolecules that undergo a new mechanism of degradation with an acid amplified, sigmoidal rate. This trigger-responsive self-amplified degradable polymer undergoes accelerated rate of degradation and agent release.
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