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Updated: Jan 30, 2026

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
Published on: November 29, 2019
Total Syntheses and Configuration Assignments of JBIR-06 and Related Depsipeptides
Chie Hamada1, Yoshinosuke Usuki1, Daiki Takeuchi1
1Department of Chemistry, Graduate School of Science , Osaka City University , 3-3-138 Sugimoto, Sumiyoshi , Osaka 558-8585 , Japan.
Abstract:
The first total syntheses of JBIR-06 and two analogous depsipeptides, 12-membered antimycin-class antibiotics, have been accomplished via Shiina macrolactonization. Comparison of the spectroscopic data of the synthesized compounds with those reported for natural products verified that the absolute configutation of the natural products was (2 S,4 S,6 S,7 R,14 S).
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