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Cancer Target Gene Screening: a web application for breast cancer target gene screening using multi-omics data

Hyung-Yong Kim1, Hee-Joo Choi1,2, Jeong-Yeon Lee3

  • 1Department of Pathology, College of Medicine, Hanyang University, Seoul, Republic of Korea.

Briefings in Bioinformatics
|January 31, 2019
PubMed

Insights

A new web tool, Cancer Target Gene Screening (CTGS), aids breast cancer research by analyzing multi-omics data. It helps identify potential therapeutic targets and biomarkers for improved patient outcomes.

Area of Science:

  • Oncology
  • Bioinformatics
  • Genomics

Background:

  • Breast cancer presents diverse molecular subtypes with varied clinical outcomes, necessitating advanced research tools.
  • Understanding the biological complexity and identifying novel prognostic/therapeutic markers are crucial for incurable subtypes.

Purpose of the Study:

  • To develop an accessible analytical tool for comprehensive multi-omics data analysis in breast cancer.
  • To facilitate the identification of clinically significant genes and potential therapeutic targets.

Main Methods:

  • Development of Cancer Target Gene Screening (CTGS), a web application for analyzing multi-omics data from primary breast tumors.
  • Integration of genomic, epigenomic, and transcriptomic data with survival and correlation analyses.
  • Genome-wide screening function to prioritize candidate genes based on alterations and expression.

Main Results:

  • CTGS enables rapid, user-friendly investigation of genomic and epigenomic aberrations, transcriptomic profiles, and survival analyses.
  • The tool integrates multi-omics data to prioritize candidate genes with copy number alterations, DNA methylation, and dysregulated expression.
  • Prioritized genes are of potential clinical and biological significance within specific breast cancer subgroups.

Conclusions:

  • CTGS provides a valuable platform for breast cancer research, aiding in the discovery of druggable cancer driver genes.
  • The application supports subtype-specific and condition-specific identification of therapeutic targets.
  • CTGS is accessible online for broader research community utilization.
Keywords:
breast cancer subtypecancer target gene screeningclinical implicationsgenetic aberrationmulti-omicssurvival analysis

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