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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Sensory Functions of the Skin01:16

Sensory Functions of the Skin

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Accessory Structures of the Skin: Nails01:05

Accessory Structures of the Skin: Nails

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Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
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Related Experiment Video

Updated: Jan 30, 2026

Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses
07:45

Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses

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How stiff is skin?

Helen K Graham1, James C McConnell2, Georges Limbert3,4

  • 1Division of Musculoskeletal& Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

Experimental Dermatology
|January 31, 2019
PubMed
Summary
This summary is machine-generated.

Understanding skin

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Area of Science:

  • Biomechanics
  • Dermatology
  • Biomaterials

Background:

  • Measuring skin's mechanical properties is crucial for understanding aging, diseases, and engineered skin.
  • Current biomechanical studies are often inaccessible due to complex terminology and analysis methods.
  • In vivo devices provide relative, not formal, mechanical measures, hindering study comparison.

Purpose of the Study:

  • To clarify key biomechanical concepts related to skin.
  • To discuss factors influencing mechanical property measurements.
  • To propose an integrated strategy for characterizing skin's mechanical behavior.

Main Methods:

  • Review of macro- and micromechanical measurement techniques.
  • Discussion of mathematical and computational modeling approaches.
  • Exploration of 3D X-ray imaging and mechanics methods.

Main Results:

  • Technical and biological factors (apparatus, scale, donor age, site) significantly affect mechanical property measurements.
  • Current methods present challenges in accessibility and comparability.
  • An integrated approach combining various techniques is needed.

Conclusions:

  • Standardizing biomechanical analysis and terminology is essential for broader accessibility.
  • Integrating macro-, micro-, and imaging-based mechanical methods offers a comprehensive strategy.
  • This unified approach will improve characterization of skin's mechanical behavior.