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Prevention and control of neoplasms associated with HPV in high-risk groups in Mexico City: The Condesa Study

Eduardo Lazcano-Ponce1, Jorge Salmerón2, Andrea González3

  • 1Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública. Cuernavaca, México.

Salud Publica De Mexico
|January 31, 2019
PubMed
Abstract

Insights

Combining human papillomavirus (HPV) vaccination with HPV screening can lower HPV infection rates and reduce the incidence of HPV-related cancers in high-risk populations. This strategy is key to preventing anogenital and oropharyngeal neoplasms.

Area of Science:

  • Oncology
  • Infectious Diseases
  • Public Health

Background:

  • Human papillomavirus (HPV) is a major cause of anogenital and oropharyngeal cancers.
  • Certain populations, including men who have sex with men, people with HIV, homeless individuals, transgender women, female sex workers, and rape victims, are at higher risk for HPV infection and related neoplasms.

Purpose of the Study:

  • To evaluate the effectiveness of a combined strategy of HPV vaccination and high-risk HPV screening.
  • To assess the reduction in anogenital and oropharyngeal neoplasms in high-risk populations.

Main Methods:

  • Mixed methods study utilizing Kaplan-Meier and time-to-event analysis.
  • Evaluation of HPV prevalence/incidence and occurrence of cervical and anal intraepithelial neoplasms grade 2+.
  • Tracking time from positive HPV results to the incidence of HPV-type-specific anogenital lesions.

Main Results:

  • Individuals receiving HPV vaccination and undergoing primary HPV screening are expected to exhibit lower HPV prevalence and incidence.
  • This combined approach is anticipated to lead to a reduced frequency of HPV-related anogenital and oropharyngeal lesions.

Conclusions:

  • The study aims to provide scientific evidence supporting the efficacy of a combined HPV vaccination and screening strategy.
  • This approach is projected to significantly decrease the burden of HPV-associated neoplasms in vulnerable populations.
Keywords:
Condesa StudyHPV vaccinesMexicocancer screening

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