The potential use of mechanism-based enzyme inactivators in medicine

Synthesis and evaluation of dipeptide amides containing N omega-nitroarginine and D-2,4-diaminobutyric acids as inhibitors of neuronal nitric oxide synthase.

Journal of enzyme inhibition·2001

Mild and selective sodium azide mediated cleavage of p-nitrobenzoic esters.

Organic letters·2001

Short, highly efficient syntheses of protected 3-azido- and 4-azidoproline and their precursors.

Organic letters·2001

Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase.

Journal of medicinal chemistry·2001

Inactivation of C30A trimethylamine dehydrogenase by N-cyclopropyl-alpha-methylbenzylamine, 1-phenylcyclopropylamine, and phenylhydrazine.

Biochemistry·2001

Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine: mass spectral evidence for the flavin adduct.

Bioorganic & medicinal chemistry letters·2001

Lauryl gallate inhibits the activity of protein tyrosine kinase c-Src purified from human platelets.

Journal of enzyme inhibition·2002

An invertase inhibitory protein from Pteris deflexa link fronds.

Journal of enzyme inhibition·2002

Inhibition of jack bean urease by N-(n-butyl) thiophosphorictriamide and N-(n-butyl) phosphorictriamide: determination of the inhibition mechanism.

Journal of enzyme inhibition·2002

Carbonic anhydrase inhibitors: metal complexes of a sulfanilamide derived Schiff base and their interaction with isozymes I, II and IV.

Journal of enzyme inhibition·2002

Quantitative structure-activity relationship study on tetrahydro-beta-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundus.

Journal of enzyme inhibition·2002

Carbonic anhydrase inhibitors: allylsulfonamide, styrene sulfonamide, N-allyl sulfonamides and some of their Si, Ge, and B derivatives.

Journal of enzyme inhibition·2002

From Fragment Hit to Clinical Candidate: Discovery of Dual H1R/H4R Ligands with Superior Efficacy in Allergic Conjunctivitis.

Journal of medicinal chemistry·2026

Design, Synthesis, and Antitumor Activity Evaluation of Novel Dual A2A/A2B Adenosine Receptor Antagonists.

Journal of medicinal chemistry·2026

Structure-Function Analysis of the Benzyloxy Moiety of the Delta-Opioid Receptor Positive Modulator BMS-986187: Identification of a Derivative with High Selectivity for the Delta-Opioid Receptor over the Mu-Opioid Receptor In Vitro and In Vivo.

Journal of medicinal chemistry·2026

Homocamptothecin Payloads with Enhanced Potency for Antibody-Drug Conjugates.

Journal of medicinal chemistry·2026

A Series of Aryl-Substituted-(biphenyl)methyl-sulfinylmethylthiazoles as Novel and Atypical Dopamine Transporter Inhibitors.

Journal of medicinal chemistry·2026

Cyclometalated Palladium Complexes as Promising Anti-Mycobacterial Agents: Synthesis, Biological Evaluation, and Mechanism Characterization.

Journal of medicinal chemistry·2026

Related Experiment Videos

The potential use of mechanism-based enzyme inactivators in medicine

Related Concept Videos

Synthesis and evaluation of dipeptide amides containing N omega-nitroarginine and D-2,4-diaminobutyric acids as inhibitors of neuronal nitric oxide synthase.

Mild and selective sodium azide mediated cleavage of p-nitrobenzoic esters.

Short, highly efficient syntheses of protected 3-azido- and 4-azidoproline and their precursors.

Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase.

Inactivation of C30A trimethylamine dehydrogenase by N-cyclopropyl-alpha-methylbenzylamine, 1-phenylcyclopropylamine, and phenylhydrazine.

Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine: mass spectral evidence for the flavin adduct.

Lauryl gallate inhibits the activity of protein tyrosine kinase c-Src purified from human platelets.

An invertase inhibitory protein from Pteris deflexa link fronds.

Inhibition of jack bean urease by N-(n-butyl) thiophosphorictriamide and N-(n-butyl) phosphorictriamide: determination of the inhibition mechanism.

Carbonic anhydrase inhibitors: metal complexes of a sulfanilamide derived Schiff base and their interaction with isozymes I, II and IV.

Quantitative structure-activity relationship study on tetrahydro-beta-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundus.

Carbonic anhydrase inhibitors: allylsulfonamide, styrene sulfonamide, N-allyl sulfonamides and some of their Si, Ge, and B derivatives.

From Fragment Hit to Clinical Candidate: Discovery of Dual H1R/H4R Ligands with Superior Efficacy in Allergic Conjunctivitis.

Design, Synthesis, and Antitumor Activity Evaluation of Novel Dual A2A/A2B Adenosine Receptor Antagonists.

Structure-Function Analysis of the Benzyloxy Moiety of the Delta-Opioid Receptor Positive Modulator BMS-986187: Identification of a Derivative with High Selectivity for the Delta-Opioid Receptor over the Mu-Opioid Receptor In Vitro and In Vivo.

Homocamptothecin Payloads with Enhanced Potency for Antibody-Drug Conjugates.

A Series of Aryl-Substituted-(biphenyl)methyl-sulfinylmethylthiazoles as Novel and Atypical Dopamine Transporter Inhibitors.

Cyclometalated Palladium Complexes as Promising Anti-Mycobacterial Agents: Synthesis, Biological Evaluation, and Mechanism Characterization.

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The potential use of mechanism-based enzyme inactivators in medicine

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