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Published on: February 17, 2023
Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga Laurencia obtusa
Walied Mohamed Alarif1, Sultan Semran Al-Lihaibi2, Nahed Obaid Bawakid3
1Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, P.O. Box 80207, Jeddah 21589, Saudi Arabia. walied1737@yahoo.com.
Abstract:
Three new rare C12 acetogenins (enyne derivatives 1⁻3) were isolated from the organic extract obtained from the red alga Laurencia obtusa, collected from the Red Sea. The chemical structures of the isolated compounds were established by spectroscopical data analyses. Potent anti-inflammatory effect of the isolated metabolites was evidenced by inhibition of the release of inflammatory mediators (e.g., TNF-α, IL-1β and IL-6) by employing Human Peripheral Blood Mononuclear Cells (PBMC).
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