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Updated: Jan 30, 2026
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Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
Published on: September 13, 2017
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Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case-Control Study, Human Cell Cultures, and In
Nobumi Suzuki1,2,3, Ryota Niikura4, Sozaburo Ihara4,2
1Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. nsuzuki-ham@umin.ac.jp.
Cancer Prevention Research (Philadelphia, Pa.)
|February 1, 2019
Summary
This study identified potential colorectal cancer preventative drugs, excluding aspirin. Alpha-blockers, like doxazosin, showed promise by suppressing cancer cell growth and reducing tumor formation in mouse models.
Area of Science:
- Oncology
- Pharmacology
- Gastroenterology
Background:
- Colorectal cancer (CRC) prevention strategies are crucial, with aspirin being a known agent.
- Identifying novel drug candidates for CRC prevention is an ongoing research priority.
Purpose of the Study:
- To identify existing medications that may prevent colorectal cancer (CRC) beyond aspirin.
- To evaluate the efficacy of candidate drugs in preclinical models.
Main Methods:
- A retrospective case-controlled analysis of 3,120 patients (1,560 CRC, 1,560 controls) aged ≥20 years.
- Comparison of medication histories between CRC patients and matched controls.
- In vitro testing on human colorectal cancer cell lines and in vivo testing using an inflammation-induced mouse model.
Main Results:
- Multiple drug classes, including alpha-blockers and xanthine oxidase inhibitors, were associated with reduced CRC risk.
- Doxazosin (an alpha-blocker) inhibited colorectal cancer cell proliferation in vitro.
- Doxazosin demonstrated a reduction in tumorigenesis in an AOM/DSS mouse model.
Conclusions:
- Alpha-blockers, specifically doxazosin, show potential as colorectal cancer preventative agents.
- Further investigation into alpha-blockers for CRC prevention is warranted.
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