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Updated: Jun 14, 2026
07:34
FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
The map of chromosome 20.
1Department of Paediatrics, Queen's University, Kingston, Ontario, Canada.
Journal of Medical Genetics
|December 1, 1988
Summary
Human chromosome 20 gene mapping has recently accelerated, with new assignments including disease-related genes and DNA sequences. This progress enhances our understanding of genetic disorders and chromosome function.
Area of Science:
- Human Genetics
- Molecular Biology
- Genomics
Background:
- Gene assignments to human chromosome 20 were limited until recently.
- The Ninth Human Gene Mapping Workshop (HGM9) marked a significant update.
Purpose of the Study:
- To detail the updated gene and DNA sequence assignments for human chromosome 20.
- To highlight genes on chromosome 20 associated with specific diseases and biological functions.
Main Methods:
- Compilation and review of gene mapping data presented at HGM9.
- Analysis of gene functions and associated diseases for chromosome 20 loci.
Main Results:
- HGM9 provisionally added 13 genes, 10 DNA sequences for RFLPs, and one fragile site to chromosome 20.
- Five disease-related genes identified: adenosine deaminase, growth hormone releasing factor, arginine vasopressin/oxytocin neurophysins, and galactosialidosis.
- Other notable genes include the prion protein gene, SRC1, and HCK tyrosine kinases.
Conclusions:
- Recent advancements have significantly expanded the gene map of human chromosome 20.
- Chromosome 20 harbors genes critical for various functions and implicated in several human diseases.
- Further research is needed to understand the role of chromosome 20 in certain cancers and diseases.
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