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Khat: a plant with amphetamine effects.
1Department of Pharmacology, University Medical Center, Geneva, Switzerland.
Journal of Substance Abuse Treatment
|January 1, 1988
Summary
Khat (Catha edulis) leaves contain cathinone, a stimulant causing CNS effects similar to amphetamines. Understanding khat
Area of Science:
- Pharmacology
- Neuroscience
- Public Health
Background:
- Khat (Catha edulis) chewing is prevalent in East Africa and the Arabian Peninsula.
- Psychic dependence on khat is observed in some users.
- Recent research elucidates the pharmacological mechanisms behind khat's stimulant effects.
Purpose of the Study:
- To describe the khat habit and its associated health effects.
- To discuss treatment strategies for acute khat intoxication.
- To provide an updated overview of khat's pharmacology.
Main Methods:
- Review of existing literature on khat's pharmacology and clinical effects.
- Analysis of reported cases of khat intoxication.
- Pharmacological assessment of cathinone's mechanism of action.
Main Results:
- The primary psychoactive compound in khat is the alkaloid cathinone.
- Cathinone acts as a central nervous system (CNS) stimulant, comparable to amphetamines.
- Documented cases of khat intoxication have emerged globally, including in the USA and UK.
Conclusions:
- Khat consumption poses significant health risks, including dependence and intoxication.
- Cathinone's stimulant properties necessitate further research into its long-term effects.
- Effective management strategies for acute khat intoxication are crucial for public health.