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Abnormal Biodistribution on 99mTc-Red Blood Cell-Labeled Multigated Acquisition in the Presence of Suspected Cold

Robert Massey1, Jennifer S Jurgens2

  • 1Nuclear Medicine Service, Walter Reed National Military Medical Center, Bethesda, Maryland robert.massey.ctr@mail.mil.

Journal of Nuclear Medicine Technology
|February 1, 2019
PubMed

Insights

A 99mTc-red blood cell (RBC) scan revealed unusual radiotracer distribution in a patient with suspected cold agglutinin disease. This finding highlights potential imaging challenges in rare autoimmune hemolytic anemias.

Area of Science:

  • Nuclear Medicine
  • Hematology
  • Immunology

Background:

  • Multigated acquisition (MUGA) using technetium-99m-labeled red blood cells (99mTc-RBC) assesses cardiac function.
  • Cold agglutinin disease is a rare autoimmune hemolytic anemia causing RBC destruction.

Observation:

  • An atypical biodistribution pattern of 99mTc-RBCs was observed during a MUGA scan.
  • This observation occurred in a patient with suspected cold agglutinin disease.

Findings:

  • The study documents an altered biodistribution of radiolabeled RBCs.
  • This alteration is linked to the presence of cold agglutinin disease.

Implications:

  • Suspected cold agglutinin disease may affect the accuracy of cardiac imaging procedures like MUGA scans.
  • Awareness of this interaction is crucial for accurate interpretation of nuclear cardiology studies in affected patients.

Keywords:
99mTc-red blood cellscardiologycold agglutinin diseasehematologymultigated acquisitionradiopharmaceuticals

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