Related Experiment Video

Updated: Jan 30, 2026

Synthesizing Sodium Tungstate and Sodium Molybdate Microcapsules via Bacterial Mineral Excretion

Synthesizing Sodium Tungstate and Sodium Molybdate Microcapsules via Bacterial Mineral Excretion

Published on: January 30, 2018

Sodium thiosulfate and pamidronate for treatment of calciphylaxis: case report

Sonia Fernández Cañabate¹, Cristina Lucas Alvarez², Luis Ortega Valin¹

¹Complejo Asistencial Universitario de León, Servicio de Farmacia, León, España.

Colombia Medica (Cali, Colombia)

|February 1, 2019

Abstract

Introduction:

Calciphylaxis is an infrequent disease that almost exclusively affects patients with chronic kidney disease, although cases have been observed in patients without renal function impairment. The diagnosis is mainly made by clinical manifestations and subsequently confirmed by radiological and histological study. The optimal treatment is not known, although there is a consensus that a multifactorial approach is required.

Clinical Case:

A 68-year-old woman on hemodialysis for 2 years, who presented a painful nodular lesion in the left thigh, a skin biopsy was performed resulting in a diagnosis of calciphylaxis.

Treatment And Outcome:

Treatment was started with intravenous sodium thiosulfate. Pamidronate is added intravenously, three months later, due to an unfavorable evolution. After 6 months of treatment, improvement in nodular lesions and healing of the ulcerated lesion was observed to be generally well tolerated treatment.

Conclusion:

The combined treatment of sodium thiosulfate, pamidronate and calcitomimetics has been effectiveand safe for the treatment of calciphylaxis, inducing complete remission.

Keywords:

Arterioles Calciphylaxis Hyperparathyroidism Hyperphosphatemia Hypoalbuminemia pamidronate sodium thiosulfate

More Related Videos

Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems

Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems

Published on: April 26, 2019

A BW Reporter System for Studying Receptor-Ligand Interactions

A BW Reporter System for Studying Receptor-Ligand Interactions

Published on: January 7, 2019

Related Concept Videos

Regulation of Sodium and Potassium

Regulation of Sodium and Potassium

The regulation of sodium and potassium ion concentrations in the human body is a complex process governed primarily by hormones such as aldosterone, antidiuretic hormone (ADH), and atrial natriuretic peptide (ANP).
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily...

Data Reporting and Recording

Data Reporting and Recording

Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...

Roles of Electrolytes: Sodium and Potassium

Roles of Electrolytes: Sodium and Potassium

Sodium plays a crucial role in maintaining fluid and electrolyte balance and overall bodily homeostasis. Sodium balance is primarily regulated by kidney function, which adjusts sodium elimination to match dietary intake and maintain proper electrolyte levels. Sodium is the most abundant cation in the extracellular fluid (ECF) and is found in salts such as sodium chloride (NaCl) and sodium bicarbonate (NaHCO3). Although cellular plasma membranes are relatively impermeable to sodium, its role in...

Types of Reports I: Hands-off Report

Types of Reports I: Hands-off Report

A hand-off report, also known as a change-of-shift report, is a crucial nursing process that ensures the smooth transition of patient care responsibilities between nursing staff.
Following are the key components and categories of hand-off reports:
Purpose and Process:

Types of Reports II: Incident or Occurrence Report

Types of Reports II: Incident or Occurrence Report

An Incident or Occurrence Report in a healthcare setting is a crucial document used to record any unexpected occurrence that may or may not have affected a patient, employee, or visitor. Such reports are critical to improving patient safety and include all details leading up to and including the event.
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...

Antiepileptic Drugs: Sodium Channel Blockers

Antiepileptic Drugs: Sodium Channel Blockers

Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...

Articles linked to this work by shared authors, journal, and citation graph.

Polypharmacy among HIV infected people aged 50 years or older.

Colombia medica (Cali, Colombia)·2020

The Use of Antihypertensive Medication and the Risk of Breast Cancer in a Case-Control Study in a Spanish Population: The MCC-Spain Study.

PloS one·2016

A Prospective Study of Adherence and Virologic Failure in HIV-Infected Patients: Role of a Single Determination of Plasma Levels of Antiretroviral Medications.

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)·2007

See all related articles