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Related Experiment Videos

The hand in mixed connective tissue disease.

R A Lewis, J P Adams, N L Gerber

    The Journal of Hand Surgery
    |May 1, 1978
    PubMed
    Summary

    Mixed connective tissue disease (MCTD) presents unique hand manifestations, including flexor tightness, distinct from other autoimmune conditions. Some cases improve with steroids, while severe instances may require surgery, indicating a unique disease process.

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    Area of Science:

    • Rheumatology
    • Immunology
    • Orthopedics

    Background:

    • Mixed connective tissue disease (MCTD) is a recognized syndrome with distinct clinical and serological features.
    • Understanding hand involvement in MCTD is crucial for accurate diagnosis and management.

    Observation:

    • Patients with MCTD exhibited unique hand characteristics compared to systemic lupus, rheumatoid arthritis, and systemic sclerosis.
    • Radiological examination revealed no erosive changes in 10 MCTD patients, all of whom presented with Raynaud's phenomenon.
    • A prominent clinical observation was significant flexor tightness in the hands.

    Findings:

    • Mild flexor tightness responded to systemic steroid treatment.
    • One patient with severe flexor tightness necessitated surgical intervention for adhesions resulting from chronic inflammation of fascia, muscle, and tenosynovium.

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  • Biochemical analysis indicated an abnormal collagen pattern potentially specific to MCTD.

    • Implications:

    • These findings suggest that hand manifestations, particularly flexor tightness, can be a distinguishing feature of MCTD.
    • The distinct collagen pattern may serve as a biomarker for MCTD.
    • Tailored treatment strategies for hand involvement in MCTD are warranted, considering both medical and surgical options.