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Changing Hearts and Minds: Improving Outcomes in Cancer Treatment-Related Cardiotoxicity

Nonniekaye Shelburne1,2, Naoko I Simonds3, Bishow Adhikari4

  • 1Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD, USA. nshelburne@nih.gov.

Current Oncology Reports
|February 1, 2019
PubMed

Insights

Cancer treatments can harm the heart, causing serious health issues for survivors. Recent research highlights progress and identifies new priorities for preventing and managing cancer treatment-related cardiotoxicity.

Area of Science:

  • Cardiology
  • Oncology
  • Translational Science

Background:

  • Cardiotoxicity from cancer therapies is a significant cause of morbidity and mortality in cancer survivors.
  • Previous workshops in 2013 and 2018 identified key challenges and research directions.

Purpose of the Study:

  • To review advances in understanding and managing cancer treatment-related cardiotoxicity since 2013.
  • To outline updated scientific priorities for future research in this field.

Main Methods:

  • Convening of a "Changing Hearts and Minds" Workshop by the National Cancer Institute and National Heart, Lung, and Blood Institute in June 2018.
  • Review of progress in basic and clinical cardiotoxicity research.
  • Identification of knowledge gaps and promising research opportunities.

Main Results:

  • Increased National Institutes of Health funding and coordination for cardiotoxicity research since 2013.
  • Identification of over 20 new research opportunities in basic and clinical cardiotoxicity.
  • Significant progress in understanding mechanisms, detection, management, and prevention of cardiotoxicity.

Conclusions:

  • Substantial progress has been made in addressing cancer treatment-related cardiotoxicity.
  • Critical knowledge gaps remain, necessitating continued research and funding.
  • Future research priorities have been identified to improve outcomes for cancer survivors.
Abstract

Keywords:
Cancer treatmentCardio-oncologyCardiotoxicityCardiovascular disease

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