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Related Experiment Video

Updated: Jan 30, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Sleep Abnormalities in Multiple Sclerosis.

Giorgos K Sakkas^1,2, Christoforos D Giannaki³, Christina Karatzaferi^4,5

¹School of Physical Education and Sport Science, University of Thessaly, Trikala, Greece. gksakkas@gmail.com.

Current Treatment Options in Neurology

|February 1, 2019

Summary

Sleep disorders are common in multiple sclerosis (MS), impacting quality of life for many. Treatment involves lifestyle changes and cognitive therapy, with personalized medicine offering future hope.

Keywords:

Circadian Fatigue Immune-mediated diseases Melatonin Quality of life Survival

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Published on: December 26, 2015

Area of Science:

Neurology
Sleep Medicine
Immunology

Background:

Sleep abnormalities affect approximately 60% of multiple sclerosis (MS) patients.
Pathophysiology involves multifactorial elements including circadian rhythm disorders and inflammation.
Factors like immunotherapy side effects and lesion load contribute to sleep disruption.

Purpose of the Study:

To review documented sleep disorders in multiple sclerosis (MS) patients.
To highlight the impact of these sleep disorders on patients' quality of life.

Main Methods:

Literature review of well-documented sleep disorders in MS.
Focus on recent findings regarding pathophysiology and treatment.

Main Results:

Common sleep disorders include insomnia, sleep-related movement disorders, sleep-related breathing disorders, and circadian rhythm disorders.
Pro-inflammatory cytokines and lesion load are implicated in sleep disturbances.
Current treatments focus on behavioral cognitive therapy, lifestyle modification, and melatonin.

Conclusions:

Sleep disorders are a significant, complex issue in MS, affecting quality of life.
Further research into personalized medicine is crucial for improving patient outcomes.
Addressing sleep disturbances is key to enhancing quality of life and life expectancy in MS.