Related Experiment Video
Updated: Aug 10, 2026
Microscopic Replantation of Penile Glans Amputation Due to Circumcision
Published on: June 3, 2022
A Surgeon's Guide to the Various Antibiotic Dips Available During Penile Prosthesis Implantation
Soum D Lokeshwar1, Joshua Bitran1, Vinayak Madhusoodanan1
1Department of Urology, University of Miami Miller School of Medicine, 1120 NW 14th Street, 15th Floor, Miami, FL, 33136, USA.
Purpose Of Review:
Inflatable penile prosthesis (IPP) is a treatment for erectile dysfunction. IPPs have undergone improvements; however, post-surgical infections still occur. Furthermore, the type of pathogens infecting the implants has changed recently from Gram-positive to Gram-negative bacteria and fungi due to advances in antibiotic dips targeting the skin flora. To protect against infection, the AMS 700 is pre-coated with InhibiZone (mixture of Rifampin/Minocycline) and the Coloplast Titan, with several antibiotic dip options of differing efficacies. This review discusses strategies to decrease the infection rates in implant surgery, focusing on antibiotic dips.
Recent Findings:
Current research endorses the use of rifampin/gentamicin as the most studied combination; however, some studies have utilized different dips for additional coverage including the InhibiZone on the AMS 700. With the increasing prevalence of diabetes and Gram-negative organisms, there is a need to develop strategies for increased coverage against infections. Controlled studies with different antibiotic combinations are needed to identify the ideal cocktail to decrease infection.
Insights
Inflatable penile prosthesis (IPP) infections are shifting towards Gram-negative bacteria and fungi. New antibiotic dip strategies are needed to combat these evolving pathogens and reduce surgical site infections.
Area of Science:
- Urology
- Infectious Disease
- Biomedical Engineering
Background:
- Inflatable penile prosthesis (IPP) implantation is a common treatment for erectile dysfunction.
- Despite IPP advancements, post-surgical infections remain a significant concern.
- Pathogen profiles have shifted from Gram-positive to Gram-negative bacteria and fungi.
Observation:
- The AMS 700 IPP features InhibiZone (Rifampin/Minocycline) coating.
- The Coloplast Titan IPP offers various antibiotic dip options.
- Rifampin/gentamicin is the most studied antibiotic combination for IPP surgery.
Findings:
- Current antibiotic strategies may not fully address the rise in Gram-negative infections.
- The efficacy of different antibiotic dips varies.
- There is a need for further research into optimal antibiotic combinations.
Implications:
- Developing novel antibiotic dip strategies is crucial to reduce IPP infection rates.
- Increased coverage against Gram-negative organisms and fungi is necessary.
- Controlled studies are required to determine ideal antibiotic cocktails for IPP surgery.
Related Concept Videos
01:23Hand hygiene
Hand washing...
01:26Standard Precaution
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
01:26Urine Studies II: Urine Culture and Sensitivity Test