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[Acyclovir in herpes neonatorum].

J Schumann1

  • 1Deutsche Wellcome GmbH, Med. Wissenschaftliche Abt., Burgwedel 1.

Klinische Padiatrie
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

Vaginal delivery can transmit genital herpes (HSV) from mother to newborn. Most newborns are protected by maternal antibodies, but some infections may go undiagnosed due to lack of visible symptoms.

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Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Medicine
  • Infectious Diseases

Context:

  • Genital herpes (HSV) in pregnant women poses a significant risk of neonatal infection during vaginal delivery.
  • Asymptomatic viral shedding occurs in 2.4% of pregnant women with a history of HSV at term.
  • Neonatal herpes infections can result from intrapartum transmission.

Purpose:

  • To highlight the risks of neonatal herpes transmission during vaginal delivery.
  • To discuss the role of maternal antibodies in protecting newborns.
  • To address the diagnostic challenges posed by asymptomatic neonatal herpes infections.

Summary:

  • Vaginal delivery is a primary route for neonatal herpes infection, stemming from maternal genital herpes.
  • Maternal antibodies, transferred via the placenta, often protect term infants from infection.

Related Experiment Videos

  • Neonatal herpes infection occurs at a rate of 1-5 per 10,000 deliveries, with 50% lacking visible skin manifestations, leading to potential misdiagnosis.

    • Impact:

    • Emphasizes the importance of recognizing asymptomatic maternal shedding of HSV.
    • Underscores the need for vigilant diagnosis of neonatal herpes, even without cutaneous signs.
    • Informs clinical practice regarding the management and prevention of neonatal herpes transmission.