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Prognostic value of hyperuricemia in patients with acute coronary syndrome: A meta-analysis

Cuifang He1, Peihuan Lin1, Wenbing Liu1

  • 1Department of CCU, The No.6 People's Hospital, Huizhou, China.

European Journal of Clinical Investigation
|February 1, 2019
PubMed

Insights

Elevated uric acid levels, or hyperuricemia, independently predict major adverse cardiovascular events and death in acute coronary syndrome (ACS) patients. This finding can improve risk stratification for ACS outcomes.

Area of Science:

  • Cardiology
  • Clinical Biochemistry

Background:

  • The prognostic value of elevated uric acid in acute coronary syndrome (ACS) patients remains debated.
  • Hyperuricemia is a common finding in patients with cardiovascular disease.

Purpose of the Study:

  • To evaluate the prognostic significance of hyperuricemia in patients diagnosed with acute coronary syndrome (ACS).
  • To assess the association between high uric acid levels and adverse cardiovascular outcomes in ACS patients.

Main Methods:

  • A systematic literature search was conducted across multiple databases (PubMed, Embase, VIP, CNKI, WanFang) up to June 2018.
  • Included observational studies investigating hyperuricemia and its association with major adverse cardiovascular events (MACEs), all-cause mortality, or cardiovascular mortality in ACS patients.

Main Results:

  • Nine studies involving 8776 ACS patients were analyzed.
  • Hyperuricemia was associated with a significantly increased risk of MACEs (RR: 1.86), all-cause mortality (RR: 1.86), and cardiovascular mortality (RR: 1.74) after adjusting for conventional risk factors.
  • Stratified analyses confirmed the consistent prognostic significance of hyperuricemia across subgroups.

Conclusions:

  • Hyperuricemia serves as an independent predictor of adverse outcomes, including MACEs and mortality, in ACS patients.
  • Measuring uric acid levels holds potential for enhancing the risk stratification of ACS patients.
Abstract

Keywords:
acute coronary syndromemajor adverse cardiac eventsmeta-analysismortalityuric acid

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