Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chromosome Replication

Chromosome Replication

Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins. This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin...

DNA Replication

DNA Replication

DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied. After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication...

Replication in Prokaryotes

Replication in Prokaryotes

Replication in Eukaryotes

Replication in Eukaryotes

The DNA Replication Fork

The DNA Replication Fork

An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork. Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication...

Random Error

Random Error

Random or indeterminate errors originate from various uncontrollable variables, such as variations in environmental conditions, instrument imperfections, or the inherent variability of the phenomena being measured. Usually, these errors cannot be predicted, estimated, or characterized because their direction and magnitude often vary in magnitude and direction even during consecutive measurements. As a result, they are difficult to eliminate. However, the aggregate effect of these errors can be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Interobserver Agreement among a Staff Member and Visitors at a Wolf Sanctuary.

Behavior analysis in practice·2024

Same author

Recent research on response disequilibrium theory: A concise review.

Journal of applied behavior analysis·2024

Same author

The effects of response disequilibrium on social media use: A laboratory analogue.

Behavioural processes·2024

Same author

The Effects of Obligatory and Preferential Frames on Delay Discounting.

The Analysis of verbal behavior·2020

Same author

An Empirical Evaluation of the Disequilibrium Model to Increase Independent Seatwork for an Individual Diagnosed with Autism.

Behavior analysis in practice·2020

Same author

Coal Is Not Black, Snow Is Not White, Food Is Not a Reinforcer: The Roles of Affordances and Dispositions in the Analysis of Behavior.

The Behavior analyst·2020

Same journal

The Genoeconomics of Impulsive Intertemporal Choice: A Critical Review.

Journal of the experimental analysis of behavior·2026

Same journal

Shaping the extinction burst: Increasing its probability and preventing its emergence across topographies.

Journal of the experimental analysis of behavior·2026

Same journal

Evaluating the combined effects of effort and probability on monetary discounting.

Journal of the experimental analysis of behavior·2026

Same journal

An improved translational approach to studying persistence-strengthening effects of differential reinforcement of alternative behavior.

Journal of the experimental analysis of behavior·2026

Same journal

Interactions between the effects of food and water motivating operations on concurrent food- and water-reinforced responding in mice.

Journal of the experimental analysis of behavior·2026

Same journal

Odor-visual and visual-visual matching to sample with dogs.

Journal of the experimental analysis of behavior·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 30, 2026

Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice

Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice

Published on: October 19, 2019

Replicability and randomization test logic in behavior analysis.

Kenneth W Jacobs¹

¹University of Nevada, Reno.

Journal of the Experimental Analysis of Behavior

|February 1, 2019

Summary

This summary is machine-generated.

Randomization tests offer a powerful nonparametric statistical method for analyzing treatment effects. These tests provide a potentially more useful p-value than traditional parametric methods, aiding in addressing the replication crisis in research.

Keywords:

counterfactual reasoning general process approach null hypothesis significance testing randomization tests replication crisis single-case experimental designs statistical inference

More Related Videos

High-throughput Analysis of Locomotor Behavior in the Drosophila Island Assay

High-throughput Analysis of Locomotor Behavior in the Drosophila Island Assay

Published on: November 5, 2017

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Published on: May 13, 2012

Related Experiment Videos

Last Updated: Jan 30, 2026

Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice

Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice

Published on: October 19, 2019

High-throughput Analysis of Locomotor Behavior in the Drosophila Island Assay

High-throughput Analysis of Locomotor Behavior in the Drosophila Island Assay

Published on: November 5, 2017

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Published on: May 13, 2012

Area of Science:

Behavior analysis
Nonparametric statistics
Research methodology

Background:

Parametric statistics rely on assumptions that limit their use with single-case data.
P-values from parametric statistics are frequently misinterpreted, contributing to a replication crisis.
Behavior analysts seek robust statistical methods for studying behavioral processes.

Purpose of the Study:

To describe the logic and benefits of randomization tests for behavior analysis.
To differentiate randomization test p-values from those of parametric statistics.
To address the replication crisis within the context of behavior analytic research.

Main Methods:

Explanation of randomization test principles.
Comparison of randomization tests with parametric statistical methods.
Discussion of p-value interpretation in both statistical frameworks.

Main Results:

Randomization tests do not require random sampling or distributional assumptions.
Randomization tests offer a potentially more interpretable p-value compared to parametric tests.
The logic of randomization tests aligns with the behavior analytic tradition.

Conclusions:

Randomization tests are a valuable nonparametric tool for behavior analysts.
These tests can help mitigate issues related to the replication crisis.
Randomization tests are well-suited for analyzing single-case experimental data.