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Minimal hepatic encephalopathy: current clinical and pathogenetic aspects

I V Damulin1,2

  • 1I.M. First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

Terapevticheskii Arkhiv
|February 1, 2019
PubMed

Insights

Minimal hepatic encephalopathy (MHE) involves cognitive impairment due to disrupted brain connections. Early diagnosis is crucial as MHE significantly impacts brain function and often goes unrecognized.

Area of Science:

  • Neurology
  • Gastroenterology
  • Neuroscience

Background:

  • Minimal hepatic encephalopathy (MHE) presents with subtle cognitive deficits.
  • Understanding the pathogenesis of MHE is essential for timely diagnosis and management.

Purpose of the Study:

  • To review current concepts on the clinical presentation and pathogenesis of MHE.
  • To analyze functional MRI data for insights into MHE's underlying mechanisms.

Main Methods:

  • Review of modern literature on MHE.
  • Analysis of functional magnetic resonance imaging (fMRI) data.
  • Examination of spontaneous brain activity and resting-state networks.

Main Results:

  • Cognitive impairment is a key feature of MHE.
  • Disruption of cerebral connections and altered spontaneous brain activity are implicated in MHE pathogenesis.
  • fMRI data offer new perspectives on the origins of MHE-related clinical disorders.

Conclusions:

  • MHE is a clinically significant condition despite minimal symptoms.
  • Delayed diagnosis of MHE can lead to severe cerebral function damage.
  • Cognitive deficits in MHE are associated with substantial changes in neuronal activity.
Keywords:
clinical featuresfunctional brain imagingminimal hepatic encephalopathypathogenesisresting state activity of the brain

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