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The role of the mLDL-induced activation of the complement system classical pathway and C3 expression stimulation in

O M Drapkina1, B B Gegenava1, V V Fomin1

  • 1I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Terapevticheskii Arkhiv
|February 1, 2019
PubMed

Insights

Modified low-density lipoprotein activates the complement system

Area of Science:

  • Immunology
  • Cardiovascular Science
  • Molecular Biology

Background:

  • Modified low-density lipoprotein (LDL) is implicated in atherosclerosis.
  • The complement system plays a role in inflammatory processes.

Purpose of the Study:

  • To investigate the role of modified LDL in activating the classical complement pathway.
  • To examine the effect of modified LDL on C3 gene expression in macrophages.

Main Methods:

  • Human macrophages were treated with modified LDL.
  • Complement pathway activation was assessed.
  • C3 gene expression levels were measured.

Main Results:

  • Modified LDL activated the classical pathway of the complement system.
  • Modified LDL increased C3 gene expression in human macrophages.

Conclusions:

  • Modified LDL contributes to complement activation and inflammation.
  • These processes may promote atherosclerotic vascular lesion progression.

Keywords:
complementmodified LDLthe C3 gene expressionthe classical pathway

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