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The role of podocytes dysfunction in chronic glomerulonephritis progression
N V Chebotareva1, I N Bobkova1, L V Lysenko1
1I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia.
Terapevticheskii Arkhiv
|February 1, 2019
Summary
Podocyte damage in chronic glomerulonephritis causes proteinuria and glomerulosclerosis. Podocyturia, the presence of podocytes in urine, indicates injury and predicts disease progression.
Area of Science:
- Nephrology
- Pathology
Background:
- Chronic glomerulonephritis involves podocyte injury.
- Podocyte damage is a key factor in proteinuria and glomerulosclerosis progression.
Purpose of the Study:
- To review mechanisms of podocyte damage in chronic glomerulonephritis.
- To discuss podocyte injury markers and assessment methods.
Main Methods:
- Review of experimental and clinical studies.
- Analysis of podocyte response to damage (cytoskeleton changes, effacement, detachment).
- Examination of podocyturia and podocyte-specific proteins in urine.
Main Results:
- Podocyte damage involves actin cytoskeleton reorganization, foot process effacement, and detachment.
- Podocyturia and podocyte-specific proteins in urine are markers of injury.
- Massive podocyturia leads to podocytopenia and glomerulosclerosis.
Conclusions:
- Podocyte injury mechanisms are crucial in chronic glomerulonephritis.
- Podocyturia assessment offers a method to evaluate glomerular damage and glomerulosclerosis risk.
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