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HCV-associated mixed cryoglobulinemia and b-cell non-Hodgkin's lymphoma - pathogenetically related problems
S Yu Milovanova1, L V Lysenko Kozlovskaya1, L Yu Milovanova1
1I.M. Sechenov First Moscow State Medical Univesity, Ministry Health of Russia (Sechenov University), Moscow, Russia.
Insights
Hepatitis C virus (HCV) significantly increases the risk of developing non-Hodgkin's lymphoma (NHL). Antiviral therapy shows effectiveness in treating HCV-associated NHL, offering a crucial treatment avenue.
Area of Science:
- Hepatology
- Oncology
- Immunology
Background:
- Hepatitis C virus (HCV) infection is a global health concern with significant hepatic and extrahepatic manifestations.
- Mixed cryoglobulinemia (CG), an extrahepatic manifestation of HCV, is recognized as a B-cell lymphoproliferative disorder.
- Epidemiological studies and treatment outcomes suggest a link between HCV and lymphoproliferative diseases like non-Hodgkin's lymphoma (NHL).
Purpose of the Study:
- To review current literature on the role of HCV in the pathogenesis of NHL.
- To present a meta-analysis of epidemiological data investigating the association between HCV and NHL development.
- To discuss therapeutic strategies for HCV-associated NHL, including antiviral therapy and chemotherapy.
Main Methods:
- Comprehensive literature search for recent studies on HCV and NHL.
- Meta-analysis of epidemiological data to quantify the risk of NHL in HCV-infected individuals.
- Review of treatment outcomes for HCV-associated NHL.
Main Results:
- Evidence confirms the significant role of HCV in the pathogenesis of NHL.
- Antiviral therapy has demonstrated effectiveness in treating HCV-associated NHL.
- Chemotherapy remains an option for managing HCV-associated NHL.
Conclusions:
- HCV infection is a critical factor in the development of NHL.
- Antiviral treatment is a viable and effective therapeutic option for HCV-associated NHL.
- Further research into the mechanisms and optimal management of HCV-associated NHL is warranted.
Abstract:
Hepatitis C virus (HCV) is a global population problem due to its high prevalence, usually late diagnosis, the difficulties of treatment. In the prognosis of patients with HCV not only hepatic, but increasingly frequent of extrahepatic HCV manifestations, such as mixed cryoglobulinemia (CG), are important. Mixed CG is currently considered as a B-cell benign lymphoproliferative disorders. The role of HCV virus in the pathogenesis of lymphoproliferative diseases is confirmed by a large number of epidemiological studies, as well as by the effectiveness of antiviral therapy in patients with non-Hodgkin's lymphoma (NHL). The purpose of the review was to provide an overview of recent literature data and the meta-analysis of epidemiological data explaining the role of HCV in the development of NHL. The review also discusses the treatment for HCV-associated NHL by antiviral therapy or other therapeutic options, such as chemotherapy.