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[Immunopathogeny of pemphigus]
L Squiquera1, G J Anhalt, L A Diaz
1Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Medicina Cutanea Ibero-Latino-Americana
|January 1, 1988
Abstract:
This article reviews recent concepts of pathogenetic mechanisms in pemphigus. We describe the pathogenic effect of the autoantibodies, the animal model for the disease and the ultrastructural alterations which follow the antibody-antigen interaction. The role of complement and protease systems in development of tissue injury are also discussed.