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NSAID-induced enteropathy: the current state of the problem
A A Svistunov1, M A Osadchuk1, N V Kireeva1
1I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia.
Terapevticheskii Arkhiv
|February 1, 2019
Summary
This review examines how nonsteroidal anti-inflammatory drugs (NSAIDs) cause intestinal damage (NSAID-enteropathy), focusing on the gut microbiota
Area of Science:
- Gastroenterology
- Microbiology
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used but can cause significant gastrointestinal side effects.
- NSAID-induced enteropathy is a serious condition affecting the small intestine.
Purpose of the Study:
- To analyze the etiological and pathogenetic mechanisms of NSAID-enteropathy.
- To highlight the role of intestinal microbiota in NSAID-enteropathy.
- To evaluate the therapeutic potential of probiotics.
Main Methods:
- Literature review of existing studies on NSAID-enteropathy.
- Analysis of research on the gut microbiome and its interaction with NSAIDs.
- Examination of studies investigating probiotic interventions.
Main Results:
- NSAID-enteropathy involves complex mechanisms including direct mucosal injury and altered gut barrier function.
- Intestinal microbiota dysbiosis plays a crucial role in the development and progression of NSAID-enteropathy.
- Probiotics show promise in mitigating NSAID-induced intestinal damage.
Conclusions:
- Understanding the pathogenesis of NSAID-enteropathy is key to developing effective treatments.
- Targeting the intestinal microbiota, particularly with probiotics, offers a promising strategy for prevention and management of NSAID-enteropathy.
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