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Biologics for hidradenitis suppurativa: an update

Katarzyna Włodarek1, Małgorzata Ponikowska1, Łukasz Matusiak1

  • 1Department of Dermatology, Venereology & Allergology, Medical University, Wroclaw, Poland.

Immunotherapy
|February 1, 2019
PubMed

Insights

Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition. Biologics, like adalimumab, offer a promising new treatment approach when conventional therapies fail, with others under evaluation.

Area of Science:

  • Dermatology
  • Immunology

Background:

  • Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease.
  • Its complex pathogenesis involves multifactorial causes, making treatment challenging.
  • Elevated proinflammatory cytokines are observed in HS patients.

Purpose of the Study:

  • To review the role of biologics in managing hidradenitis suppurativa.
  • To highlight current therapeutic options and emerging treatments for HS.

Main Methods:

  • Review of existing literature on HS pathogenesis and treatment.
  • Analysis of clinical trial data for biologic agents in HS.
  • Evaluation of the efficacy and safety of approved and investigational biologics.

Main Results:

  • Adalimumab is the sole internationally registered biologic for HS, recommended after conventional therapies.
  • Infliximab and etanercept have demonstrated efficacy and safety in randomized trials.
  • New biologic agents are under investigation, requiring further rigorous evaluation.

Conclusions:

  • Biologics represent a significant advancement in HS therapy.
  • Adalimumab is a key treatment option, with other biologics showing potential.
  • Ongoing research is crucial for developing novel and effective HS treatments.

Keywords:
acne inversabiologic drugsbiologic therapybiologicshidradenitis suppurativamanagementtherapytreatment

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