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Biologics for hidradenitis suppurativa: an update
Katarzyna Włodarek1, Małgorzata Ponikowska1, Łukasz Matusiak1
1Department of Dermatology, Venereology & Allergology, Medical University, Wroclaw, Poland.
Immunotherapy
|February 1, 2019
Summary
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition. Biologics, like adalimumab, offer a promising new treatment approach when conventional therapies fail, with others under evaluation.
Area of Science:
- Dermatology
- Immunology
Background:
- Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease.
- Its complex pathogenesis involves multifactorial causes, making treatment challenging.
- Elevated proinflammatory cytokines are observed in HS patients.
Purpose of the Study:
- To review the role of biologics in managing hidradenitis suppurativa.
- To highlight current therapeutic options and emerging treatments for HS.
Main Methods:
- Review of existing literature on HS pathogenesis and treatment.
- Analysis of clinical trial data for biologic agents in HS.
- Evaluation of the efficacy and safety of approved and investigational biologics.
Main Results:
- Adalimumab is the sole internationally registered biologic for HS, recommended after conventional therapies.
- Infliximab and etanercept have demonstrated efficacy and safety in randomized trials.
- New biologic agents are under investigation, requiring further rigorous evaluation.
Conclusions:
- Biologics represent a significant advancement in HS therapy.
- Adalimumab is a key treatment option, with other biologics showing potential.
- Ongoing research is crucial for developing novel and effective HS treatments.
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