Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

4.9K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.9K
Trial and Error and Algorithm01:12

Trial and Error and Algorithm

404
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
404
Clinical Trials01:16

Clinical Trials

10.4K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.4K
Random Error01:04

Random Error

9.8K
Random or indeterminate errors originate from various uncontrollable variables, such as variations in environmental conditions, instrument imperfections, or the inherent variability of the phenomena being measured. Usually, these errors cannot be predicted, estimated, or characterized because their direction and magnitude often vary in magnitude and direction even during consecutive measurements. As a result, they are difficult to eliminate. However, the aggregate effect of these errors can be...
9.8K
Random Variables01:09

Random Variables

17.8K
A random variable is a single numerical value that indicates the outcome of a procedure. The concept of random variables is fundamental to the probability theory and was introduced by a Russian mathematician, Pafnuty Chebyshev, in the mid-nineteenth century.
Uppercase letters such as X or Y denote a random variable. Lowercase letters like x or y denote the value of a random variable. If X is a random variable, then X is written in words, and x is given as a number.
For example, let X = the...
17.8K
Randomized Experiments01:13

Randomized Experiments

9.0K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
9.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The speed of innovation versus the speed of validation: A growing governance gap in contemporary endodontics.

European journal of oral sciences·2026
Same author

A Protocol for the Development of a Three-Dimensional Classification of Endodontic Lesions Scheduled for Surgery.

International endodontic journal·2026
Same author

Understanding the Content and Purpose of S3 Clinical Practice Guidelines in Dentistry.

International endodontic journal·2026
Same author

Short-Term Outcomes of Full Pulpotomy Compared With Root Canal Treatment for Irreversible Pulpitis: The PROVE Study.

International endodontic journal·2026
Same author

Pre-Eruptive Intracoronal Resorption: Report of Two Cases.

Reports (MDPI)·2026
Same author

Extended Reality in Endodontics: A Review of Current Applications and Future Potential.

International endodontic journal·2026

Related Experiment Video

Updated: Jan 30, 2026

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.5K

Preferred Reporting Items for RAndomized Trials in Endodontics (PRIRATE) guidelines: a development protocol.

V Nagendrababu1, H F Duncan2, L Bjørndal3

  • 1Division of Clinical Dentistry, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.

International Endodontic Journal
|February 1, 2019
PubMed
Summary
This summary is machine-generated.

New Preferred Reporting Items for RAndomized Trials in Endodontics (PRIRATE) guidelines will improve the quality of endodontic research. These evidence-based guidelines aim to enhance the reporting and planning of randomized clinical trials in endodontics.

Keywords:
endodonticshealth research reporting guidelinesprotocolrandomized clinical trial

More Related Videos

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
03:53

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

2.9K
Guided Endodontics: Three-Dimensional Planning and Template-Aided Preparation of Endodontic Access Cavities
07:14

Guided Endodontics: Three-Dimensional Planning and Template-Aided Preparation of Endodontic Access Cavities

Published on: May 24, 2022

5.2K

Related Experiment Videos

Last Updated: Jan 30, 2026

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.5K
Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
03:53

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

2.9K
Guided Endodontics: Three-Dimensional Planning and Template-Aided Preparation of Endodontic Access Cavities
07:14

Guided Endodontics: Three-Dimensional Planning and Template-Aided Preparation of Endodontic Access Cavities

Published on: May 24, 2022

5.2K

Area of Science:

  • Endodontics
  • Clinical Research Methodology
  • Evidence-Based Dentistry

Background:

  • Randomized clinical trials (RCTs) are crucial for clinical decision-making.
  • Existing reporting guidelines like CONSORT have limitations in improving RCT manuscript quality.
  • Suboptimal reporting quality in endodontic RCTs necessitates specialized guidelines.

Purpose of the Study:

  • To develop and disseminate the Preferred Reporting Items for RAndomized Trials in Endodontics (PRIRATE) guidelines.
  • To enhance the planning and reporting quality of RCTs in endodontics.
  • To establish a standardized framework for endodontic trial reporting.

Main Methods:

  • A steering committee developed an initial draft of the PRIRATE guidelines.
  • A five-stage consensus process involving a PRIRATE Delphi Group (PDG) and a PRIRATE Face-to-face Consensus Meeting Group (PFCMG) was employed.
  • Items were evaluated using a 9-point Likert scale, with consensus achieved through iterative Delphi rounds and face-to-face meetings.

Main Results:

  • The consensus process, involving expert groups, led to the development of the PRIRATE guidelines.
  • The guidelines aim to address specific reporting needs in endodontic research.
  • An accompanying explanation and elaboration document will support guideline implementation.

Conclusions:

  • The PRIRATE guidelines provide a robust framework for improving endodontic RCT reporting.
  • Dissemination to academic institutions and societies will promote adoption.
  • Periodic revisions will ensure the guidelines remain current and relevant.