Related Experiment Video

Updated: Jan 30, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

1.0K

Perioperative olfactory dysfunction in patients with meningiomas of the anteromedial skull base

Philipp Hendrix1, Gerrit Fischer1, Alan-Christopher Linnebach1

  • 1Department of Neurosurgery, Saarland University Medical Center and Saarland University Faculty of Medicine, Homburg, Saarland, Germany.

Clinical Anatomy (New York, N.Y.)
|February 1, 2019
PubMed

Insights

Olfactory dysfunction is common in patients with supratentorial meningiomas, especially olfactory groove meningiomas (OGM). Older age, midline shift, OGM resection, and surgical complications increase the risk of olfactory loss.

Area of Science:

  • Neurosurgery
  • Otolaryngology
  • Neurology

Background:

  • Olfactory dysfunction is a primary symptom of olfactory groove meningiomas (OGM).
  • Olfactory function in patients with supratentorial meningiomas is understudied.
  • Investigating pre- and postoperative olfactory function is crucial for patient outcomes.

Purpose of the Study:

  • To explore variables associated with olfactory dysfunction in patients with supratentorial meningiomas.
  • To compare olfactory function in patients with meningiomas affecting the olfactory system versus those with meningiomas in other locations.
  • To identify risk factors for preoperative and postoperative olfactory dysfunction.

Main Methods:

  • Retrospective study of supratentorial meningioma patients undergoing resection (January 2015 - January 2016).
  • Olfactory performance assessed using a lateralized "Sniffin' Stick" odor identification test pre- and postoperatively.
  • Comparison between meningiomas affecting the olfactory system (n=23) and control group (n=40).

Main Results:

  • Meningiomas affecting the olfactory system were associated with ipsilateral (OR 3.6) and bilateral (OR 3.7) anosmia.
  • Preoperative anosmia risk factors included midline shift and older age.
  • Postoperative ipsilateral anosmia risk increased significantly with olfactory system meningiomas (OR 11.1), particularly OGMs.
  • Surgical complications increased risk of contralateral (OR 12.3) and bilateral (OR 27.8) olfactory loss.

Conclusions:

  • Older age and frontal base midline shift predispose to preoperative olfactory dysfunction.
  • OGM resection and surgical complications are significant risk factors for postoperative olfactory deterioration.
  • Preoperative olfactory testing is critical for surgical planning in OGM cases to preserve function.
Keywords:
meningiomaolfaction disordersolfactory nerveolfactory nerve diseases

More Related Videos

Fertility Preservation in Patients with Severe Ovarian Dysfunction12:03

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Published on: March 25, 2021

5.0K
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

4.3K

Related Concept Videos

Sutures of the Skull01:22

Sutures of the Skull

The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
10.3K
Overview of the Skull01:08

Overview of the Skull

The cranium (skull) is the skeletal structure of the head that supports the face and protects the brain. It is subdivided into the facial bones and the brain case, or cranial vault. The facial bones underlie the facial structures, form the nasal cavity, enclose the eyeballs, and support the teeth of the upper and lower jaws.
The cranial vault surrounds and protects the brain and houses the middle and inner ear structures. This cavity is bounded superiorly by the rounded top of the skull, which...
7.8K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
12.7K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
11.7K
Patient-centered Care01:13

Patient-centered Care

Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
3.0K
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
269