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Long-term Chronological Changes in Very Asymmetric Keratoconus.
Shizuka Koh1,2, Ryota Inoue1,3, Naoyuki Maeda2
1Department of Innovative Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan.
Cornea
|February 1, 2019
Summary
Long-term monitoring of forme fruste keratoconus is crucial, especially in younger patients with asymmetric keratoconus. Corneal tomography reveals significant changes over time, particularly in curvature, emphasizing careful observation.
Area of Science:
- Ophthalmology
- Corneal Imaging
- Keratoconus Research
Background:
- Keratoconus (KC) is a progressive corneal ectasia.
- Very asymmetric KC presents diagnostic challenges.
- Scheimpflug imaging aids in corneal analysis.
Purpose of the Study:
- To evaluate chronological changes in very asymmetric keratoconus using Scheimpflug tomography.
- To identify progression patterns in forme fruste keratoconus.
Main Methods:
- Retrospective review of 382 KC patients.
- Inclusion of patients with unilateral KC and contralateral forme fruste KC.
- Analysis of anterior and posterior radius of curvature (ARC, PRC) and thinnest pachymetry (Tmin) over a mean follow-up of 6.3 years.
Main Results:
- Significant annual increase in posterior radius of curvature (PRC) with longer follow-up (P=0.011).
- Greater annual increase in anterior radius of curvature (ARC) observed in younger patients at initial examination (P<0.001).
Conclusions:
- Long-term clinical follow-up is essential for forme fruste keratoconus, even with initially stable measurements.
- Younger patients with very asymmetric keratoconus require vigilant monitoring due to observed progression patterns.
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