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Updated: Jan 30, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: A
Pei-Pei Wang1, Xi Zhou2, Xi Chen1
1Department of Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuaifuyuan 1#, Beijing 100730, P. R. China.
Rationale:
Malignant melanoma with indiscoverable skin manifestations is unusual and refractory hypercalcemia with high metabolic signal of the rectum as initial manifestation is very rare.
Patient Concerns:
We present a case that presented with paresis, nausea, and vomiting.
Diagnoses:
Malignant melanoma with spinal metastasis.
Interventions And Outcomes:
The patient underwent posterior decompression, partial tumor resection, bone cement reconstruction, and internal fixation. The patient's hypercalcemia was controlled and muscle strength was partially recovered. The immunohistochemical stainings showed Melan-A (+), HMB45 (+), s-100 (+), Vimentin (+), and AE1/AE3 (-).
Lessons:
We emphasize the necessity of screening potential existence of neoplasms for the patients with hypercalcemia. Surgical treatment is still necessary for patients with spinal metastasis.
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