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Risk factors for developing Mycobacterium kansasii lung disease: A case-control study in Korea

Jin Hyoung Kim1, Kwang Won Seo1, Yongjoon Shin2

  • 1Department of Internal Medicine.

Medicine
|February 1, 2019
PubMed

Insights

Heavy industry jobs and low body mass index (BMI) are key risk factors for developing Mycobacterium kansasii lung disease (MKLD). Higher education may offer some protection against MKLD development.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Epidemiology

Background:

  • Previous studies on Mycobacterium kansasii lung disease (MKLD) risk factors are outdated and lack robust statistical analysis.
  • Known associations include COPD, pneumoconiosis, aging, male sex, immunosuppression, alcohol, malignancy, and occupations like mining and sandblasting.

Purpose of the Study:

  • To identify current, independent risk factors for developing MKLD in Korea.
  • To utilize appropriate statistical methodologies for accurate risk factor assessment.

Main Methods:

  • Retrospective case-control study involving 86 MKLD patients and 172 controls (1:2 ratio) from January 2010 to December 2014.
  • Data collected via medical records review and telephone surveys, including clinical and demographic characteristics.
  • Multivariate logistic regression analysis performed to determine independent risk factors.

Main Results:

  • Occupation in heavy industries emerged as a significant risk factor (aOR 6.41, P=.001).
  • Low body mass index (BMI) was independently associated with increased MKLD risk (aOR 0.73 per kg/m, P<.001).
  • Educational attainment above high school level showed a protective effect (aOR 0.22, P=.005).

Conclusions:

  • Employment in heavy industries and low BMI are identified as significant independent risk factors for MKLD in the Korean population.
  • Higher educational attainment may be associated with a reduced risk of developing MKLD.

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