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Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells

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Published on: January 21, 2021

On-chip stool liquefaction via acoustofluidics.

Shuaiguo Zhao¹, Weihua He, Zhehan Ma

¹Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA. tony.huang@duke.edu.

|February 1, 2019

Summary

This study introduces the first microfluidic chip using acoustic streaming to liquefy stool samples, enabling portable gut microbiota analysis. This innovation overcomes a key hurdle for developing standalone stool diagnostic platforms.

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Area of Science:

Biomedical Engineering
Microfluidics
Gastroenterology

Background:

Microfluidic devices are crucial for analyzing stool biomarkers and gut microbiota.
Processing stool samples in microfluidics presents significant challenges, limiting standalone platform development.

Purpose of the Study:

To develop the first microfluidic chip capable of liquefying stool samples using acoustic streaming.
To enable robust stool sample preparation for microfluidic analysis.

Main Methods:

Utilized acoustic streaming generated by an acoustic transducer to homogenize stool samples and buffers.
Employed an array of 100 μm micropillars for subsequent purification of homogenized stool samples.
Assessed chip biocompatibility by examining bacteria morphology and viability.

Main Results:

Successfully liquefied stool samples of varying consistencies using acoustic streaming.
Demonstrated effective homogenization at flow rates up to 30 μL min-1.
Confirmed favorable biocompatibility of the acoustofluidic chip for bacterial samples.

Conclusions:

The developed acoustofluidic chip provides a miniaturized, robust, and biocompatible solution for stool sample preparation.
This technology can be integrated into portable stool diagnostic platforms.
Addresses a critical need for efficient stool processing in microfluidic diagnostic devices.