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Updated: Jan 30, 2026

A Micropatterning Assay for Measuring Cell Chirality
Published on: March 11, 2022
Simultaneous Construction of Planar and Central Chiralities as Well as Unprecedented Axial Chirality on and around a
Hongjie Li1, Peijing Jia1, Naixin Qian1
1Key Laboratory of Radiopharmaceuticals, College of Chemistry , Beijing Normal University , Beijing 100875 , P.R. China.
Abstract:
Simultaneous generation of planar, central and axial chiralities on and around a ferrocene backbone via a d-phenylglycinol-induced intramolecular iminium cyclization was disclosed, which is rare and differs from known methods. A series of chiral spiro[cyclopentadienyl-1,2,3,3a-tetrahydropentalenyliron(II)-1,2'-pyrrolidine] derivatives were prepared acording to the new method, and their structures were characterized unambiguously. The axial chirality caused by the ferrocene backbone and the rigid spiral structure was verified by NOESY and variable-temperature NMR experiments and single-crystal XRD analyses. Mechanism for the stereoselective iminium cyclization reaction was suggested, which was influenced by steric hindrance and hydrogen bonding.
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