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Updated: Jan 30, 2026
08:36
A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
Published on: March 17, 2016
8.5K
White matter in different regions evolves differently during progression to dementia.
Mahsa Dadar1, Josefina Maranzano2, Simon Ducharme3
1NeuroImaging and Surgical Tools Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Neurobiology of Aging
|February 1, 2019
Summary
White matter hyperintensities (WMHs) indicate tissue damage in mild cognitive impairment (MCI). Increased WMH volume and decreased T1w intensity in specific brain regions predict conversion to dementia.
Area of Science:
- Neurology
- Neuroimaging
- Gerontology
Background:
- White matter hyperintensities (WMHs) are prevalent in mild cognitive impairment (MCI) and Alzheimer's disease.
- Higher WMH volumes in MCI correlate with increased risk of progressing to Alzheimer's disease.
Purpose of the Study:
- To compare WMH volume and T1w hypointensity in stable MCI versus MCI converters to dementia.
- To investigate WMH burden as a surrogate of vascular disease in MCI progression.
Main Methods:
- Analysis of WMH volume and T1w hypointensity in periventricular, deep, and juxtacortical regions.
- Comparison between stable MCI (N=413) and MCI converters (N=178).
Main Results:
- MCI converters showed significantly greater increases in all regional WMH volumes.
- Juxtacortical WMH T1w hypointensity was lower in converters and age-independent.
- Conversion to dementia was associated with decreased intensity, not volume, of periventricular and juxtacortical WMHs.
Conclusions:
- WMH volume and T1w hypointensity patterns differ between stable MCI and converters.
- Regional differences in WMHs suggest distinct pathological mechanisms in dementia progression.
- T1w hypointensity, particularly in juxtacortical and periventricular regions, is a key indicator for MCI conversion to dementia.
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