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Gait abnormalities in minimally disabled people with Multiple Sclerosis: A 3D-motion analysis study
Marianna Liparoti1, Marida Della Corte2, Rosaria Rucco3
1Department of Motor Sciences and Wellness, University of Naples "Parthenope", Via Medina 40, Naples 80133, Italy.
Multiple Sclerosis and Related Disorders
|February 1, 2019
Summary
Three-dimensional gait analysis (3D-GA) detects subtle gait impairments in people with Relapsing-Remitting Multiple Sclerosis (pwRR-MS) even when they are cognitively preserved. These gait abnormalities, including reduced velocity and stability, are evident during both single and cognitive dual tasks.
Area of Science:
- Neurology
- Biomechanics
- Rehabilitation Science
Background:
- Relapsing-Remitting Multiple Sclerosis (pwRR-MS) can cause subclinical gait impairment.
- The Expanded Disability Status Scale may not detect subtle gait issues.
- Three-dimensional Gait Analysis (3D-GA) can identify minor gait abnormalities.
Purpose of the Study:
- Investigate gait patterns in minimally disabled pwRR-MS using 3D-GA.
- Assess gait during single tasks (SinT) and cognitive dual tasks (CogDT).
- Correlate gait parameters with cognitive scores, lesion load (LL), and brain atrophy.
Main Methods:
- 22 pwRR-MS and 21 healthy controls (HCs) participated.
- Neuropsychological (NP) evaluation and brain MRI were performed.
- 3D-GA was used to analyze gait patterns.
Main Results:
- pwRR-MS showed impaired velocity, stability, and kinematic parameters compared to HCs during SinT.
- These gait alterations persisted during CogDT, with increased double limb support.
- No significant correlations were found between gait abnormalities and cognitive status or MRI measures.
Conclusions:
- 3D-GA can detect subclinical gait abnormalities in asymptomatic and cognitively preserved pwRR-MS.
- Gait impairment is present even in early stages of MS.
- 3D-GA offers a sensitive tool for assessing gait in pwRR-MS.
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