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Emergence of Neisseria meningitidis W135 in Cote d'Ivoire: laboratory based-surveillance

Man-Koumba Soumahoro1, Clarisse Kouamé-Elogne2, Jean-Claude Anné2

  • 1Département Epidémiologie Recherche Clinique, Institut Pasteur de Côte d'Ivoire, Abidjan, Cote d'lvoire.

Epidemiology and Health
|February 1, 2019
PubMed
Abstract

Insights

Neisseria meningitidis (Nm) W135 emerged in Côte d'Ivoire, replacing NmA. Enhanced surveillance is crucial for early detection of new bacterial serogroups causing meningitis.

Area of Science:

  • Epidemiology
  • Microbiology
  • Public Health

Background:

  • Neisseria meningitidis (Nm) is a leading cause of bacterial meningitis.
  • Serogroup W135 (NmW135) has emerged globally, posing a significant public health threat.
  • Understanding serogroup dynamics is vital for effective meningitis control strategies.

Purpose of the Study:

  • To document the emergence and characteristics of Neisseria meningitidis W135 (NmW135) in Côte d'Ivoire.
  • To compare NmW135 with Neisseria meningitidis A (NmA) in terms of prevalence and distribution.
  • To analyze trends in meningococcal serogroup circulation within the region.

Main Methods:

  • Retrospective analysis of Nm isolates from Côte d'Ivoire's National Reference Center (2007-2012).
  • Comparison of socio-demographic data and bacterial serotypes using Fisher exact and Wilcoxon tests.
  • Statistical analysis of geographical distribution, age, and sex in relation to serogroups.

Main Results:

  • NmW135 was the predominant serogroup (99/175 isolates), followed by NmA (57/175).
  • NmW135 showed a higher prevalence in northern health districts (85.9%) compared to NmA (45.5%).
  • NmA isolates ceased being detected after 2009, while NmW135 dominated isolates from 2010-2012.

Conclusions:

  • Neisseria meningitidis W135 has emerged in Côte d'Ivoire, coinciding with the disappearance of NmA.
  • Strengthened laboratory-based meningitis surveillance is recommended to monitor bacterial trends.
  • Early detection of emerging serogroups is essential for timely public health interventions.
Keywords:
Bacterial meningitisCote d’IvoireNeisseria meningitidisPublic health surveillance

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