Related Experiment Video

Updated: Jan 30, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

34.1K

NONVALVULAR ATRIAL FIBRILLATION AND DIABETIC NEPHROPATHY: EPIDEMIOLOGY, PROGNOSIS, AND CHOICE OF ANTICOAGULANT

Natalya A Koziolova1, E A Polyanskaya, M V Surovtseva

  • 1ФГБОУ ВО «Пермский государственный медицинский университет им. акад. Е. А. Вагнера» Минздрава России. nakoziolova@mail.ru.

Kardiologiia
|February 2, 2019
PubMed

Insights

Patients with type 2 diabetes and chronic kidney disease face higher risks of bleeding, clots, and death. Novel oral anticoagulants

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology

Background:

  • Atrial fibrillation (AF) is common in patients with type 2 diabetes (T2D), diabetic nephropathy, and chronic kidney disease (CKD).
  • Comorbidities like T2D and CKD significantly impact the risk of adverse events in AF patients.

Purpose of the Study:

  • To review the prevalence of AF in patients with T2D, diabetic nephropathy, and CKD.
  • To evaluate the efficacy and safety of anticoagulants in this complex patient population.

Main Methods:

  • Literature review of studies on AF, T2D, diabetic nephropathy, CKD, and anticoagulant use.
  • Analysis of data regarding bleeding, thromboembolic complications, and mortality risks.

Main Results:

  • Patients with nonvalvular AF, T2D, and CKD have increased risks of bleeding, thromboembolism, and all-cause death.
  • Warfarin may be less effective and increase bleeding risk in CKD due to poor INR control and arterial calcification.
  • Novel oral anticoagulants (NOACs) efficacy and safety are influenced by comorbidities, necessitating dose adjustments or alternative selections based on renal function.

Conclusions:

  • Diabetic nephropathy requires careful monitoring of renal function to guide anticoagulant choice and dosing.
  • Limited data from randomized controlled trials hinders definitive anticoagulant selection for patients with end-stage CKD, including those on hemodialysis or post-transplantation.

More Related Videos

Robotic Ablation of Atrial Fibrillation11:21

Robotic Ablation of Atrial Fibrillation

Published on: May 29, 2015

20.2K
Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats05:12

Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats

Published on: February 14, 2022

3.8K

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
11.9K
Amyloid Fibrils03:03

Amyloid Fibrils

6.4K
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.3K
Introduction to Epidemiology01:26

Introduction to Epidemiology

Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...
1.8K
Causality in Epidemiology01:21

Causality in Epidemiology

Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
1.6K
Mate Choice01:20

Mate Choice

Mate choice—the decision about whom to mate with—is a type of natural selection, since animals must reproduce to pass down their genes. Mate choice is also called intersexual selection because the behavior occurs between the sexes.
11.7K