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Ultrastructural localization of secretory granule constituent chromogranin and 7 B 2
R Y Osamura1, M Chrétien, M Marcinkiewicz
1Department of Pathology, Tokai University School of Medicine, Kanagawa-ken, Japan.
Pathology, Research and Practice
|September 1, 1988
Abstract:
Our immunoelectron microscopic pre-embedding method confirmed that chromogranin A (CGA) 7 B 2 and EGC were actual secretory granule constituents. The presence of these constituents in rough endoplasmic reticulum indicated their production in the tumor cells. Similar localization of CGA to 7 B 2 suggested that CGA may be secreted into the circulation as it is for 7 B 2. Different mechanism of granular formation is proposed between GH secreting adenomas and FSH secreting adenomas.