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Related Experiment Video

Updated: Jul 9, 2026

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

Autism spectrum disorders: let's talk about glucose?

Silvia Hoirisch-Clapauch¹, Antonio E Nardi²

¹Hospital Federal dos Servidores do Estado, Ministry of Health, Av. Atlantica 434 - 1101, Rio de Janeiro - CEP, 22010-000, Brazil. sclapauch@gmail.com.

Translational Psychiatry

|February 2, 2019

Summary

This summary is machine-generated.

Maternal glucose abnormalities, such as intrauterine hyperglycemia and neonatal hypoglycemia, may influence autism spectrum disorder (ASD) development. Lifestyle interventions and targeted screening could potentially reduce ASD prevalence.

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Area of Science:

Neuroscience
Developmental Biology
Metabolic Disorders

Background:

Autism spectrum disorders (ASD) are linked to neuronal migration defects and mitochondrial dysfunction.
Intrauterine hyperglycemia and neonatal hypoglycemia are implicated in pathways affecting neuronal development.

Purpose of the Study:

To investigate the relationship between maternal and offspring glucose abnormalities and ASD risk factors.
To explore the potential role of hyperglycemia and hypoglycemia in ASD pathogenesis.

Main Methods:

Literature search using PubMed with "autism spectrum disorder" and "risk factors".
Analysis of the association between identified risk factors and maternal/neonatal glucose levels.
Review of rodent studies on intrauterine hyperglycemia and medication effects.

Main Results:

Strong links exist between glucose abnormalities (obesity, maternal diabetes) and ASD risk factors.
Connections between malformations, SSRI exposure, and glucose issues are speculative but supported by animal models.
Maternal high-carbohydrate diets or inactivity can affect neonatal glucose levels, with some hypoglycemia cases missed by current screening.

Conclusions:

Maternal glycemic control and enhanced neonatal hypoglycemia screening, considering lifestyle and prenatal medication exposure, may be crucial for reducing ASD prevalence.
Further controlled studies are necessary to validate these interventions.