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Coagulation abnormalities associated with localized hemorrhage in the neonate
The Journal of Pediatrics
|June 1, 1978
Summary
Serial coagulation studies in neonates with localized hemorrhage revealed increased factor VIII, low platelets, and short PTT. These findings suggest similar mechanisms to disseminated intravascular coagulation, aiding in detecting occult bleeding in infants.
Area of Science:
- Neonatal medicine
- Hematology
- Pediatric coagulation
Background:
- Localized hemorrhage in neonates presents diagnostic challenges.
- Understanding coagulation profiles is crucial for neonatal care.
Observation:
- Serial coagulation studies were performed on six neonates with various localized hemorrhages (intracranial, gastrointestinal, subperiosteal, pulmonary).
- Key coagulation parameters were analyzed in these infants.
Findings:
- Consistently observed findings included elevated factor VIII levels.
- A decreased platelet count and a shortened partial thromboplastin time (PTT) were also noted.
- These coagulation abnormalities resemble those seen in disseminated intravascular coagulation.
Implications:
- The findings suggest that similar pathophysiological mechanisms may underlie both localized hemorrhage and disseminated intravascular coagulation in neonates.
- Serial coagulation studies can serve as a valuable tool for suspecting occult or clinically unrecognized hemorrhage in sick infants.
- This approach may improve early diagnosis and management of bleeding complications in newborns.