Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

3.2K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.2K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.1K
Adult Stem Cells01:33

Adult Stem Cells

33.8K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.8K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.5K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.5K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

2.7K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.7K
Understanding the Self01:28

Understanding the Self

283
The self is a central aspect of human identity, encompassing an individual’s beliefs, emotions, perceptions, and experiences. It is a cognitive and psychological construct that enables individuals to interpret their traits and behaviors, influencing how they perceive themselves and interact with the world. While personality consists of stable and enduring characteristics, the self is shaped by self-perception and social experiences. This distinction highlights the dynamic nature of the...
283

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The mRNA export pathway licenses viral mimicry response and antitumor immunity by actively exporting nuclear retroelement transcripts.

Science translational medicine·2025
Same author

PRMT2 promotes HIV-1 latency by preventing nucleolar exit and phase separation of Tat into the Super Elongation Complex.

Nature communications·2023
Same author

Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours.

eLife·2023
Same author

How to improve the outcomes of elderly acute myeloid leukemia patients through allogeneic hematopoietic stem cell transplantation.

Frontiers in immunology·2023
Same author

Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy.

Nature communications·2023
Same author

Identification and validation of reference genes for normalization of gene expression analysis using qRT-PCR in <i>Megalurothrips usitatus</i> (thysanoptera: thripidae).

Frontiers in physiology·2023

Related Experiment Video

Updated: Jan 30, 2026

Author Spotlight: Integrating Single-Cell Transcriptomics with Organoid Cultures for Advanced Research and Therapeutic Insights
08:23

Author Spotlight: Integrating Single-Cell Transcriptomics with Organoid Cultures for Advanced Research and Therapeutic Insights

Published on: June 28, 2024

1.4K

Recent advances in understanding intestinal stem cell regulation.

Deqing Hu1,2, Han Yan1, Xi C He3

  • 1Department of Cell Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics; Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University, Heping, Tianjin, China.

F1000Research
|February 2, 2019
PubMed
Summary

Intestinal stem cells (ISCs) maintain gut health and repair damage. This review explores ISC identity, plasticity, and regulatory mechanisms, including niche signaling and epigenetics, crucial for intestinal regeneration and preventing colorectal cancer.

Keywords:
EpigeneticsHomeostasisIntestinal stem cellNichPlasticityRegeneration

More Related Videos

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
08:55

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia

Published on: May 18, 2018

11.2K
Author Spotlight: The 3D Culturing of Organoids from Murine Intestinal Crypts and a Single Stem Cell for Organoid Research
10:39

Author Spotlight: The 3D Culturing of Organoids from Murine Intestinal Crypts and a Single Stem Cell for Organoid Research

Published on: April 7, 2023

10.0K

Related Experiment Videos

Last Updated: Jan 30, 2026

Author Spotlight: Integrating Single-Cell Transcriptomics with Organoid Cultures for Advanced Research and Therapeutic Insights
08:23

Author Spotlight: Integrating Single-Cell Transcriptomics with Organoid Cultures for Advanced Research and Therapeutic Insights

Published on: June 28, 2024

1.4K
Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
08:55

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia

Published on: May 18, 2018

11.2K
Author Spotlight: The 3D Culturing of Organoids from Murine Intestinal Crypts and a Single Stem Cell for Organoid Research
10:39

Author Spotlight: The 3D Culturing of Organoids from Murine Intestinal Crypts and a Single Stem Cell for Organoid Research

Published on: April 7, 2023

10.0K

Area of Science:

  • Gastroenterology and Regenerative Medicine
  • Cell Biology and Stem Cell Research

Background:

  • Intestinal homeostasis and regeneration rely on intestinal stem cells (ISCs) within crypts.
  • Beyond actively cycling ISCs, other stem/progenitor cell populations aid tissue repair and restore intestinal integrity after injury.
  • Dysregulation of ISCs and related cells is linked to colorectal tumorigenesis.

Purpose of the Study:

  • To review recent findings on intestinal stem cell (ISC) identity and cellular plasticity.
  • To discuss regulatory mechanisms controlling ISCs for intestinal homeostasis and regeneration.
  • To emphasize extrinsic niche-derived signaling and intrinsic epigenetic regulation in ISC control.

Main Methods:

  • Literature review of recent findings on ISC identity and plasticity.
  • Analysis of regulatory mechanisms governing ISCs.
  • Focus on extrinsic niche signaling and intrinsic epigenetic regulation.

Main Results:

  • Accumulating evidence suggests diverse stem/progenitor cell pools contribute to intestinal repair.
  • Extrinsic niche signaling and intrinsic epigenetic factors are key regulators of ISC function.
  • Understanding these mechanisms is vital for maintaining intestinal homeostasis and preventing disease.

Conclusions:

  • Precise control of ISCs and related cells is essential for intestinal homeostasis and regeneration.
  • Further research is needed to fully elucidate mechanisms of intestinal repair and injury response.
  • This review highlights critical areas for future investigation into intestinal stem cell biology.