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Exploring cocoa properties: is theobromine a cognitive modulator?

Ilaria Cova1, V Leta2,3, C Mariani3

  • 1Center for Research and Treatment on Cognitive Dysfunctions, Neurology Unit, L. Sacco University Hospital, Via G.B. Grassi, 74, I-20157, Milan, Italy. ilaria.cova@unimi.it.

Psychopharmacology
|February 2, 2019
PubMed
Summary

Theobromine, found in cocoa, may offer neuroprotection and potentially aid cognitive function, though more research is needed. Its effects are less understood than caffeine

Keywords:
CocoaCognitionCognitive modulatorTheobromine

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Area of Science:

  • Nutritional Neuroscience
  • Pharmacology

Background:

  • Cocoa is rich in flavanols with antioxidant and neuroprotective properties.
  • Methylxanthines, including caffeine and theobromine, are key active compounds in cocoa.
  • The cognitive effects of theobromine are less understood compared to caffeine.

Purpose of the Study:

  • To review the existing evidence on theobromine's effects on cognitive functions.
  • To explore the potential neuroprotective actions of theobromine.

Main Methods:

  • Review of animal and human studies investigating theobromine's impact on cognition.
  • Analysis of studies examining theobromine's role in neurodegenerative pathology.

Main Results:

  • Acute theobromine exposure shows a delayed and reduced nootropic effect compared to caffeine in animal models.
  • Long-term theobromine consumption may offer neuroprotection by reducing amyloid-beta pathology, relevant to Alzheimer's disease.

Conclusions:

  • Theobromine exhibits potential neuroprotective effects, particularly with long-term intake.
  • Further research is required to fully elucidate the cognitive and neuroprotective mechanisms of theobromine, alone and in combination with other cocoa constituents.