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Updated: Jan 30, 2026
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Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model
Published on: February 14, 2025
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Prenatal detection of right aortic arch.
Gülen Yerlikaya1, Tünay Efetürk2, Stephanie Springer3
1Department of Gynecology and Obstetrics, Division of Feto-Maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. guelen.yerlikaya@meduniwien.ac.at.
Archives of Gynecology and Obstetrics
|February 2, 2019
Summary
Right aortic arch (RAA) in fetuses is linked to various abnormalities and chromosomal issues. Genetic testing is recommended for all RAA cases to guide perinatal management and assess risks.
Area of Science:
- Fetal Medicine
- Cardiology
- Genetics
Background:
- Right aortic arch (RAA) is a congenital cardiovascular anomaly with potential associations.
- Prenatal diagnosis is crucial for appropriate perinatal management and genetic counseling.
Purpose of the Study:
- To analyze fetuses with RAA for associated anomalies and guide perinatal care.
- To determine the utility of fetal MRI in evaluating RAA cases.
Main Methods:
- Retrospective analysis of 36 fetuses with RAA diagnosed prenatally.
- Review of associated intracardiac and extracardiac malformations.
- Assessment of karyotype results and postnatal outcomes.
Main Results:
- RAA was diagnosed in 32 fetuses, and double aortic arch (DAA) in 4.
- Associated anomalies included intracardiac (19.5%) and extracardiac (30.6%) malformations.
- Chromosomal abnormalities like 22q11.2 microdeletion and trisomy 21 were identified.
Conclusions:
- RAA is frequently associated with other anomalies and chromosomal abnormalities, necessitating genetic testing.
- Fetal echocardiography can detect RAA, and fetal MRI shows promise for comprehensive assessment.
- Karyotyping is advised for all RAA cases regardless of other detected malformations.
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