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Updated: Jan 30, 2026
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A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
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Evidence-Based Consensus on Positioning of SGLT2i in Type 2 Diabetes Mellitus in Indians
Awadhesh Kumar Singh1, Ambika G Unnikrishnan2, Abdul H Zargar3
1GD Hospital and Diabetes Institute, Kolkata, West Bengal, India. singhawadheshkumar2018@gmail.com.
Summary
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) offer significant benefits for diabetes management in India, including weight and blood pressure reduction. Careful monitoring for potential side effects is essential for optimal patient outcomes.
Area of Science:
- Endocrinology
- Pharmacology
Background:
- Current diabetes management requires comprehensive strategies beyond glycaemic control.
- Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are emerging antidiabetic agents with multifaceted benefits.
Purpose of the Study:
- To review the evidence for SGLT2i in diabetes management.
- To provide recommendations for SGLT2i use in the Indian population.
Main Methods:
- Systematic literature review of Medline, Cochrane Library, and other databases.
- Evidence-based analysis for positioning SGLT2i in Indian diabetes management.
Main Results:
- SGLT2i provide moderate glycaemic control, reduce body weight and blood pressure, and lower macro/microvascular complication risks.
- Unique benefits include visceral fat loss, reduced insulin resistance, and improved beta-cell function (HOMA-β).
- Potential risks include genital infections, volume depletion, amputations, and diabetic ketoacidosis.
Conclusions:
- SGLT2i show promise for comprehensive diabetes management in India, addressing specific patient challenges.
- Individualized, patient-centric therapy is crucial to maximize benefits and minimize risks.
- Careful monitoring for adverse events is necessary during SGLT2i treatment.
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