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Intracranial Aneurysms in Sickle Cell Disease

Ramazan Jabbarli1, Thiemo F Dinger1, Daniela Pierscianek1

  • 1Department of Neurosurgery, University Hospital of Essen, Essen, Germany.

Current Neurovascular Research
|February 2, 2019
PubMed

Insights

Intracranial aneurysms (IAs) in sickle-cell disease (SCD) patients present differently than in the general population, often appearing younger and more numerous. Rupture risk factors in SCD patients largely align with those in healthy individuals.

Area of Science:

  • Neurology
  • Vascular Surgery
  • Hematology

Background:

  • Intracranial aneurysms (IAs) etiology remains unclear, though associations with certain diseases exist.
  • Sickle-cell disease (SCD) is a known condition linked to increased IA risk.

Purpose of the Study:

  • To compare the demographic and radiographic characteristics of intracranial aneurysms (IAs) in patients with sickle-cell disease (SCD) versus the general population.
  • To identify specific risk factors for IA rupture in individuals with SCD.

Main Methods:

  • Systematic literature search of PubMed, Scopus, Web of Science, and Cochrane Library for studies on SCD patients with IAs.
  • Comparison of IA characteristics between 129 SCD patients and 2451 healthy IA carriers from an observational cohort.

Main Results:

  • SCD patients with IAs were younger (mean 27.1 vs 54.9 years) with a lower female prevalence.
  • Multiple IAs were more prevalent (47% vs 34.5%) and numerous (3.02 vs 2.56 IAs/patient) in the SCD cohort.
  • IAs were smaller in SCD patients (unruptured: 3.27 vs 6.16 mm) and more frequently located in the internal carotid artery or posterior circulation.

Conclusions:

  • Intracranial aneurysms in SCD patients exhibit distinct demographic and radiographic patterns compared to the general population.
  • Key risk factors for IA rupture in SCD, including age, size, and location, are similar to those observed in healthy individuals.
Abstract

Keywords:
Intracranial aneurysmgrowthrisk factorsrupturesickle-cell diseasesubarachnoid hemorrhage.

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