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Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Induced by Imatinib
F Zgolli1,2, I Aouinti1,2, O Charfi1,2
1National Center Chalbi Belkahia of Pharmacovigilance, 9 Avenue du Dr Zouhaier Essafi 1006, Tunis, Tunisia.
Current Drug Safety
|February 2, 2019
Summary
A rare but severe adverse drug reaction, DRESS syndrome, can occur with imatinib treatment for gastrointestinal stromal tumors (GIST). Prompt discontinuation of imatinib led to a favorable outcome in this case.
Area of Science:
- Oncology
- Pharmacology
- Dermatology
Background:
- Imatinib is a primary treatment for advanced gastrointestinal stromal tumors (GIST).
- While generally well-tolerated, imatinib can cause adverse drug reactions (ADRs).
- Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a severe hypersensitivity reaction with characteristic symptoms.
Observation:
- A 46-year-old woman with GIST developed DRESS syndrome two weeks after initiating imatinib.
- Symptoms included rash, eosinophilia, and elevated liver function tests, with therapeutic imatinib plasma levels.
- Imatinib was discontinued, leading to a gradual positive clinical response.
Findings:
- This case of imatinib-induced DRESS syndrome was scored as probable using the Naranjo scale (score 5).
- The patient's condition improved after the cessation of imatinib therapy.
- This represents a rare but significant ADR associated with imatinib treatment.
Implications:
- Highlights the importance of recognizing DRESS syndrome as a potential ADR of imatinib in GIST patients.
- Emphasizes the need for vigilant monitoring for severe cutaneous adverse reactions during imatinib therapy.
- Underscores the critical role of early drug withdrawal for managing DRESS syndrome and ensuring patient recovery.
Keywords:
CMLDRESS syndrome imatinibDrug hypersensitivity syndromeGISTadverse drug reactionpharmacovigilance.More Related Videos
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