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I V Ponomarenko1, I A Sukmanova

  • 1Altai regional cardiological dispensary. fake@neicon.ru.

Kardiologiia
|February 2, 2019
PubMed
Summary

This study identifies key risk factors for acute coronary syndrome (ACS) in young adults, including genetic polymorphisms and lifestyle choices. Understanding these factors improves cardiovascular disease risk prediction in younger populations.

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Area of Science:

  • Cardiology
  • Genetics
  • Preventive Medicine

Background:

  • Acute coronary syndrome (ACS) affects increasingly younger individuals.
  • Identifying specific risk factors in this demographic is crucial for early intervention.
  • Genetic predispositions and lifestyle choices play a significant role in ACS development.

Purpose of the Study:

  • To investigate the association between thrombosis risk factors, gene polymorphisms, and ACS in patients aged 25-44.
  • To identify significant risk factor combinations contributing to ACS in young adults.
  • To enhance the prediction of cardiovascular disease risk in younger populations.

Main Methods:

  • A case-control study involving 299 young ACS patients and 53 healthy controls.
  • Comprehensive clinical, biochemical, and genetic analyses, including polymerase chain reaction for FII, FV, and MTHFR gene polymorphisms.
  • Multifactorial statistical analysis with binary logistic regression to identify risk factor sets.

Main Results:

  • Identified significant risk factor combinations for ACS in young patients.
  • Key factors include elevated low-density lipoproteins, reduced high-density lipoproteins, smoking, and homozygous MTHFR C677-T and FV G1691-A polymorphisms.
  • Heredity combined with smoking and MTHFR homozygosity also emerged as significant risk factors.

Conclusions:

  • Predicting cardiovascular disease risk in young individuals can be improved by considering traditional and novel risk factors.
  • Research into genetic factors like MTHFR and FV polymorphisms offers new avenues for clinical management of high-risk ACS patients.
  • A comprehensive approach integrating genetic and lifestyle factors is essential for effective ACS prevention and treatment in young adults.

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