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Posterior Cortical Atrophy.

Jonathan M Schott, Sebastian J Crutch

Continuum (Minneapolis, Minn.)

|February 2, 2019

Summary

This summary is machine-generated.

Posterior cortical atrophy (PCA) is an atypical Alzheimer's disease variant often diagnosed using new criteria. Early recognition and management are crucial for patients with this rare visual-dominant dementia.

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Area of Science:

Neuroscience
Ophthalmology
Neurology

Background:

Posterior cortical atrophy (PCA) is a rare neurodegenerative syndrome.
It often represents an atypical form of Alzheimer disease (AD).
Early-onset PCA typically presents with visual disturbances.

Purpose of the Study:

To provide a comprehensive overview of PCA.
To discuss its pathology, clinical features, diagnosis, and management.
To highlight its significance in understanding selective vulnerability in AD.

Main Methods:

Review of clinical syndrome of PCA.
Analysis of pathologic underpinnings.
Evaluation of diagnostic criteria and investigation findings.

Main Results:

New diagnostic criteria enable syndromic and disease-specific diagnosis of PCA.
Imaging reveals concordant and discordant pathologies (e.g., tau, amyloid).
Research is ongoing to identify genetic factors in sporadic PCA.

Conclusions:

PCA is a critical diagnosis for clinicians to recognize for timely intervention.
Management focuses on supportive care to enhance quality of life.
PCA offers insights into the mechanisms of AD vulnerability.