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Amaryllidaceae and Sceletium alkaloids
1State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China. zjin@nankai.edu.cn.
Natural Product Reports
|February 2, 2019
Summary
This review covers Amaryllidaceae alkaloids isolated from July 2015 to June 2017, detailing their structures, biological activities, and synthesis. It also discusses related alkaloids from Sceletium species.
Area of Science:
- Natural Product Chemistry
- Medicinal Chemistry
- Phytochemistry
Background:
- The Amaryllidaceae family is a rich source of structurally diverse alkaloids.
- Alkaloids from this family exhibit a wide range of biological activities.
- Previous reviews have highlighted progress in this field.
Purpose of the Study:
- To summarize recent advancements in the isolation and identification of Amaryllidaceae alkaloids.
- To review the biological activities and synthetic studies of these compounds.
- To discuss structurally related alkaloids from Sceletium species.
Main Methods:
- Literature review of studies published between July 2015 and June 2017.
- Analysis of reported isolation techniques and structural elucidation methods.
- Compilation of data on biological activities and synthetic approaches.
Main Results:
- Significant progress has been made in discovering novel Amaryllidaceae alkaloids.
- A wide array of biological activities, including cytotoxic and neuroprotective effects, have been reported.
- Various synthetic strategies have been developed for accessing these complex molecules.
- Structurally related alkaloids from Sceletium species are also presented.
Conclusions:
- The Amaryllidaceae family continues to be a promising source for novel bioactive natural products.
- Further research into the synthesis and pharmacological evaluation of these alkaloids is warranted.
- The review provides a comprehensive overview of the field for researchers.
