Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

NSAIDs and cartilage metabolism.

A Bjelle1

  • 1Department of Rheumatology, Sahlgren University Hospital, Gothenburg, Sweden.

Scandinavian Journal of Rheumatology. Supplement
|January 1, 1988
PubMed
Summary

Non-steroidal anti-inflammatory drugs (NSAIDs) effects on cartilage vary; some harm cartilage, while others may benefit it. Clinical data is limited, cautioning against NSAID use in osteoarthritis patients due to side effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical and ergonomic factors in prolonged shoulder pain among industrial workers.

Scandinavian journal of work, environment & health·2010
Same author

Erythrocytes aggregation in healthy donors at native and standard hematocrit: the influence of sex, age, immunoglobulins and fibrinogen concentrations. Standardization of parameters.

Clinical hemorheology and microcirculation·2007
Same author

A five-year followup of hand function and activities of daily living in rheumatoid arthritis patients.

Arthritis care and research : the official journal of the Arthritis Health Professions Association·1999
Same author

Clinical application of the measurement of spontaneous erythrocyte aggregation and disaggregation. A pilot study.

Clinical hemorheology and microcirculation·1998
Same author

Reliability, validity, and sensitivity of a Swedish version of the revised and expanded Arthritis Impact Measurement Scales (AIMS2).

The Journal of rheumatology·1997
Same author

An international study on measuring social support: interactions and satisfaction.

Social science & medicine (1982)·1996

Area of Science:

  • Biochemistry
  • Pharmacology
  • Orthopedics

Background:

  • Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for pain and inflammation.
  • Osteoarthritis is a prevalent condition, particularly in the elderly, often treated with NSAIDs.

Purpose of the Study:

  • To review experimental data on the effects of NSAIDs on cartilage.
  • To assess the clinical relevance of these experimental findings.

Main Methods:

  • Systematic review of experimental studies investigating NSAID impact on cartilage.
  • Analysis of available clinical reports on NSAID use in osteoarthritis.

Main Results:

  • Experimental data indicates that some NSAIDs can be harmful to cartilage.
  • Other NSAIDs show no negative impact on cartilage metabolism, with some potentially offering moderate benefits.
  • Clinical evidence remains scarce, necessitating cautious interpretation of experimental findings.

Conclusions:

  • NSAID effects on cartilage are drug-specific and not uniformly detrimental.
  • Limited clinical data prevents definitive conclusions on NSAID efficacy and safety in osteoarthritis.
  • Given the high incidence of adverse effects in the elderly, NSAID prescription for osteoarthritis should be approached restrictively.

Related Experiment Videos